Leukotriene transport

Across TCGA patient cohorts, RNA activity of the Leukotriene transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0E1, AKR1B10, and REPS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene transport activity versus ATP6V0E1 in CCRCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ATP6V0E1 →	+0.255	+0.567	<.001	<.001	3	4
LSCC	AKR1B10 →	+3.357	+0.589	<.001	.007	3	4
CCRCC	REPS2 →	+0.693	+0.627	.003	<.001	3	4
CCRCC	LRG1 →	+1.434	+0.884	<.001	<.001	3	4
LUAD	TMEM159 →	+0.838	+0.387	<.001	.004	3	4
CCRCC	SLC39A14 →	+1.008	+0.872	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071716 vs ATP6V0E1 — CCRCC

Explore this scatter interactively →