Leukotriene transport

Across TCGA patient cohorts, RNA activity of the Leukotriene transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABCC3, ABCC3_S908, and ABCC4_T646, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene transport activity versus ABCC3 in LUAD (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ABCC3 →	+0.913	+0.775	<.001	<.001	3	5
UCEC	ABCC3_S908 →	+1.285	+0.936	<.001	<.001	3	5
LUAD	ABCC4_T646 →	+0.964	+0.641	<.001	<.001	3	5
UCEC	SLC25A3 →	+0.838	+0.762	<.001	<.001	3	4
UCEC	SLC33A1 →	+0.803	+0.658	<.001	.002	3	4
UCEC	ATP1B1 →	+0.687	+0.579	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071716 vs ABCC3 — LUAD

Explore this scatter interactively →