Leukotriene transport

Across TCGA cell cohorts, RNA activity of the Leukotriene transport pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXA9, IVD, and SLC15A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOXA9 grouped by Leukotriene transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HOXA9 →	+0.254	+1.148	<.001	.008	3	3
LIVER	IVD →	-0.124	-1.869	.008	<.001	2	4
PANCREAS	SLC15A3 →	+0.263	+1.659	<.001	<.001	3	3
PANCREAS	TRIM47 →	+0.250	+2.268	.005	<.001	3	3
STOMACH	NAA80 →	-0.133	-1.427	.004	.001	3	3
CNS	PNN →	+0.534	+1.080	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOXA9 by Leukotriene transport activity — CNS

Explore this box plot interactively →