Leukotriene transport

Across TCGA cell cohorts, RNA activity of the Leukotriene transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SORBS1, ABHD4, and LY6D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene transport activity versus SORBS1 in OESOPHAGUS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SORBS1 →	-0.750	-1.153	.001	<.001	3	5
STOMACH	ABHD4 →	+1.657	+1.471	.007	<.001	3	4
PANCREAS	LY6D →	+3.652	+1.159	.002	.009	3	4
LARGE_INTESTINE	PSCA →	+2.545	+1.259	<.001	<.001	3	4
LARGE_INTESTINE	UBE2H →	+0.677	+0.825	.001	.006	3	4
LARGE_INTESTINE	TBC1D2 →	+1.366	+1.063	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071716 vs SORBS1 — OESOPHAGUS

Explore this scatter interactively →