Icosanoid transport

Across TCGA patient cohorts, RNA activity of the Icosanoid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AATF, KHDRBS1, and SUPT16H, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid transport activity versus AATF in LSCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AATF →	-0.447	-0.050	<.001	<.001	3	8
GBM	KHDRBS1 →	-0.276	-0.055	.001	.001	3	8
LSCC	SUPT16H →	-0.502	-0.058	<.001	<.001	3	7
OV	PNN →	-0.255	-0.037	<.001	<.001	3	7
LSCC	SART1 →	-0.283	-0.048	<.001	<.001	3	7
GBM	SMARCA4 →	-0.375	-0.057	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071715 vs AATF — LSCC

Explore this scatter interactively →