Icosanoid transport

Across TCGA cell cohorts, RNA activity of the Icosanoid transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTO1, CMTR2, and ANKRD10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSTO1 grouped by Icosanoid transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GSTO1 →	-0.813	-1.050	.008	<.001	3	4
LARGE_INTESTINE	CMTR2 →	+0.792	+0.782	<.001	.003	3	4
LARGE_INTESTINE	ANKRD10 →	+0.974	+0.799	.001	.007	3	4
BLOOD_Lymphoma	ZNF181 →	+1.963	+1.975	<.001	<.001	3	4
BREAST	DENND4C →	+0.500	+0.668	.009	.003	2	5
LUNG_NSCLC_LUSC	MIER3 →	+0.737	+0.820	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSTO1 by Icosanoid transport activity — CNS

Explore this box plot interactively →