Ectodermal placode development

Across TCGA cell cohorts, RNA activity of the Ectodermal placode development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KNG1, PPT2, and MMP23A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KNG1 grouped by Ectodermal placode development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KNG1 →	-0.162	-0.110	.002	.004	3	4
OESOPHAGUS	PPT2 →	+0.282	+0.140	<.001	<.001	3	4
LARGE_INTESTINE	MMP23A →	-0.324	-0.229	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SEMA3E →	+0.110	+0.181	.005	.004	3	4
CNS	SCAP →	+0.265	+0.114	.002	.009	3	4
CNS	TRPC1 →	+0.162	+0.112	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KNG1 by Ectodermal placode development activity — BREAST

Explore this box plot interactively →