Anatomical structure maturation

Across TCGA cell cohorts, RNA activity of the Anatomical structure maturation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK2A2, NBPF1, and BICRA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anatomical structure maturation activity versus CSNK2A2 in PANCREAS (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CSNK2A2 →	+0.473	+0.917	.006	.009	3	4
LARGE_INTESTINE	NBPF1 →	+0.706	+0.588	.003	.004	3	4
LARGE_INTESTINE	BICRA →	+0.543	+0.706	.009	.007	3	4
BLOOD_Leukemia	RIMKLB →	+1.350	+0.479	.003	.001	3	4
BLOOD_Leukemia	BICD2 →	+0.572	+0.556	.002	.007	3	4
BLOOD_Lymphoma	LZTR1 →	+0.480	+0.625	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071695 vs CSNK2A2 — PANCREAS

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