Response to indole-3-methanol

Across TCGA patient cohorts, RNA activity of the Response to indole-3-methanol pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS3, SEC23A, and COPZ2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to indole-3-methanol activity versus THBS3 in OV (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THBS3 →	+0.615	+0.078	<.001	.003	3	8
OV	SEC23A →	+0.293	+0.071	<.001	<.001	3	7
BRCA	COPZ2 →	+0.724	+0.064	<.001	<.001	3	7
OV	PPFIBP1 →	+0.310	+0.091	.004	<.001	3	7
BRCA	VCL_S795 →	+0.525	+0.069	.001	<.001	3	7
OV	DOCK11 →	+0.560	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071680 vs THBS3 — OV

Explore this scatter interactively →