Commissural neuron axon guidance

Across TCGA cell cohorts, RNA activity of the Commissural neuron axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO16, TMSB15B, and TRMT2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO16 grouped by Commissural neuron axon guidance-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FBXO16 →	-0.947	-0.719	.001	.008	3	4
BLOOD_Leukemia	TMSB15B →	-2.285	-0.316	<.001	<.001	3	4
SOFT_TISSUE	TRMT2B →	-0.532	-0.524	.009	.008	3	4
BONE	TPM1 →	-4.952	-1.568	.002	.002	3	4
KIDNEY	GEN1 →	+0.782	+1.086	.006	.003	3	3
KIDNEY	YOD1 →	+0.772	+1.148	.007	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO16 by Commissural neuron axon guidance activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →