Negative regulation of mononuclear cell migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of mononuclear cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, PRKG1, and SORBS3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mononuclear cell migration activity versus SGCD in LSCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SGCD →	+0.472	+0.071	<.001	<.001	3	9
BRCA	PRKG1 →	+0.536	+0.044	<.001	<.001	3	9
BRCA	SORBS3 →	+0.372	+0.038	<.001	.003	3	8
LSCC	SYNE1 →	+0.347	+0.072	<.001	<.001	3	8
BRCA	TNS2_S102 →	+0.848	+0.046	<.001	<.001	3	8
BRCA	DCN →	+1.026	+0.054	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071676 vs SGCD — LSCC

Explore this scatter interactively →