Negative regulation of mononuclear cell migration

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of mononuclear cell migration pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Negative regulation of mononuclear cell migration pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

BLCA, MESO, and COAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.324	0.479	.006	73	view →
MESO	OS	Quartile	II,III,IV	0.260	0.547	.004	61	view →
COAD	DFS	Quartile	All	0.448	0.692	.001	49	view →
HNSC	DFS	Quartile	IV	0.664	0.403	.001	48	view →
GBM	DFS	Quartile	All	0.083	0.383	<.001	39	view →
SKCM	DFS	Median	All	0.854	0.689	.001	37	view →
LIHC	DFS	Median	All	0.346	0.507	<.001	35	view →
UCS	DFS	Tertile	IV	0.459	0.932	.024	24	view →
SCLC	OS	Median	IV	0.201	0.772	.024	21	view →
KIRP	DFS	Median	All	0.693	0.494	.007	20	view →
CHOL	DFS	Tertile	II,III,IV	0.699	0.098	.012	18	view →
LUAD	DFS	Quartile	II,III,IV	0.555	0.327	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0071676–BLCA (OS)

Open the BLCA breakdown →