Negative regulation of mononuclear cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of mononuclear cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLRC5, OSBPL3, and SLC2A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NLRC5 grouped by Negative regulation of mononuclear cell migration-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NLRC5 →	+2.493	+1.046	<.001	.005	3	5
OVARY	OSBPL3 →	+1.196	+0.953	.007	.002	3	5
LARGE_INTESTINE	SLC2A4 →	-0.550	-0.706	.004	.004	3	4
LIVER	LGALS1 →	+3.635	+1.579	.001	<.001	3	4
LIVER	RASD2 →	+2.210	+1.794	.006	<.001	3	4
LIVER	TIMP1 →	+3.430	+1.813	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NLRC5 by Negative regulation of mononuclear cell migration activity — BLOOD_Leukemia

Explore this box plot interactively →