Negative regulation of mononuclear cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of mononuclear cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HES6, PKP3, and CYSTM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mononuclear cell migration activity versus HES6 in SKIN (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HES6 →	+2.103	+0.243	.005	.007	3	7
SKIN	PKP3 →	-2.421	-0.369	.002	<.001	3	6
SKIN	CYSTM1 →	+1.266	+0.286	<.001	<.001	3	5
SKIN	BBS5 →	+1.089	+0.233	.007	.004	3	5
BREAST	CAVIN1 →	-2.199	-0.173	.009	.002	3	5
LIVER	CHTOP →	+0.682	+0.301	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071676 vs HES6 — SKIN

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