Regulation of smooth muscle cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of smooth muscle cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KCTD12, SYNPO2_S930, and VIM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of smooth muscle cell chemotaxis activity versus KCTD12 in CCRCC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KCTD12 →	+0.244	+0.054	<.001	.001	3	9
OV	SYNPO2_S930 →	+1.015	+0.066	.007	.007	3	8
UCEC	VIM →	+0.518	+0.121	.002	.002	3	8
LSCC	CSRP1_S192 →	+0.419	+0.085	<.001	<.001	3	8
UCEC	PARVA →	+0.587	+0.131	.001	<.001	3	8
BRCA	PHYKPL →	+0.361	+0.064	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071671 vs KCTD12 — CCRCC

Explore this scatter interactively →