Negative regulation of chemokine (C-C motif) ligand 5 production

Across TCGA patient cohorts, RNA activity of the Negative regulation of chemokine (C-C motif) ligand 5 production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX58, OAS3, and SAMD9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine (C-C motif) ligand 5 production activity versus DDX58 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDX58 →	+0.678	+0.100	<.001	<.001	3	5
GBM	OAS3 →	+0.680	+0.087	<.001	<.001	3	5
HNSC	SAMD9 →	+0.492	+0.058	.001	.002	3	4
HNSC	GOLGA1 →	+0.191	+0.064	.001	.005	3	4
OV	RBM15B_S109 →	-0.668	-0.058	.005	.005	2	5
GBM	RGL2 →	-0.143	-0.064	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071650 vs DDX58 — GBM

Explore this scatter interactively →