Negative regulation of chemokine (C-C motif) ligand 5 production

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of chemokine (C-C motif) ligand 5 production pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Negative regulation of chemokine (C-C motif) ligand 5 production pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and CESC, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRP, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.582	0.744	<.001	139	view →
KIRP	DFS	Median	All	0.847	0.960	<.001	119	view →
KIRC	OS	Median	All	0.559	0.734	.002	43	view →
UVM	DFS	Median	II,III,IV	0.640	0.349	.006	36	view →
LGG	OS	Median	All	0.849	0.938	<.001	36	view →
THYM	OS	Tertile	All	0.764	1.000	.002	32	view →
LAML	DFS	Quartile	All	0.439	0.686	.014	30	view →
CESC	OS	Tertile	II,III,IV	0.826	0.498	.009	14	view →
STAD	DFS	Median	II,III,IV	0.435	0.596	.010	12	view →
BRCA	OS	Tertile	All	0.712	0.552	.023	10	view →
LUSC	DFS	Median	III,IV	0.540	0.865	.022	9	view →
ACC	OS	Median	All	0.411	0.755	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0071650–HNSC (OS)

Open the HNSC breakdown →