Negative regulation of chemokine (C-C motif) ligand 5 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine (C-C motif) ligand 5 production pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF10, NPM3, and POLD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAF10 grouped by Negative regulation of chemokine (C-C motif) ligand 5 production-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TAF10 →	+1.243	+1.701	.002	.002	3	5
OESOPHAGUS	NPM3 →	-1.106	-1.539	.009	.005	3	5
KIDNEY	POLD4 →	+1.094	+1.029	.001	.006	3	5
CNS	ZNF554 →	+0.457	+0.839	.002	.001	3	5
BLOOD_Leukemia	MTIF2 →	-0.601	-1.009	.004	.007	2	5
OESOPHAGUS	RASSF4 →	+1.308	+1.238	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF10 by Negative regulation of chemokine (C-C motif) ligand 5 production activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →