Negative regulation of chemokine (C-C motif) ligand 5 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine (C-C motif) ligand 5 production pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM120A, OR2J1, and ZFYVE26, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM120A grouped by Negative regulation of chemokine (C-C motif) ligand 5 production-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMEM120A →	-0.216	-0.691	.001	<.001	3	2
LUNG_NSCLC_LUAD	OR2J1 →	+0.148	+0.528	.002	.008	3	2
LUNG_NSCLC_LUAD	ZFYVE26 →	-0.140	-0.791	.009	.001	3	2
CNS	HTRA3 →	-0.420	-1.904	.004	<.001	3	2
LUNG_NSCLC_LUAD	TNFSF11 →	-0.220	-0.679	<.001	.008	3	2
LUNG_NSCLC_LUAD	FZD7 →	-0.151	-0.571	.007	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM120A by Negative regulation of chemokine (C-C motif) ligand 5 production activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →