Negative regulation of chemokine (C-C motif) ligand 5 production

Across TCGA cell cohorts, RNA activity of the Negative regulation of chemokine (C-C motif) ligand 5 production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDS2, MLANA, and LRRC4B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chemokine (C-C motif) ligand 5 production activity versus CDS2 in SKIN (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDS2 →	+1.121	+1.213	<.001	.005	3	3
SKIN	MLANA →	+5.370	+1.593	.003	<.001	3	3
SKIN	LRRC4B →	+2.224	+1.371	.002	<.001	3	3
SKIN	AIFM1 →	+1.102	+1.370	.003	<.001	3	3
SKIN	EDA →	+0.867	+1.301	.005	<.001	3	3
SKIN	SEC11C →	+1.060	+1.309	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071650 vs CDS2 — SKIN

Explore this scatter interactively →