Positive regulation of monocyte chemotactic protein-1 production

Across TCGA patient cohorts, RNA activity of the Positive regulation of monocyte chemotactic protein-1 production pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMSN1_S23, SASH3_S38, and SERPINB9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of monocyte chemotactic protein-1 production activity versus SAMSN1_S23 in BRCA (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAMSN1_S23 →	+0.641	+0.042	.002	.003	3	10
HNSC	SASH3_S38 →	+0.763	+0.073	<.001	<.001	3	10
UCEC	SERPINB9 →	+0.641	+0.085	<.001	<.001	3	10
UCEC	SKAP2 →	+0.863	+0.108	<.001	<.001	3	10
OV	SPN →	+0.844	+0.076	<.001	<.001	3	10
OV	SPN_S355 →	+0.952	+0.052	.003	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071639 vs SAMSN1_S23 — BRCA

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