Positive regulation of transforming growth factor beta production

Across TCGA cell cohorts, RNA activity of the Positive regulation of transforming growth factor beta production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDA3, ARID1A, and SPEN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLDA3 grouped by Positive regulation of transforming growth factor beta production-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHLDA3 →	+1.900	+0.954	<.001	<.001	3	5
BREAST	ARID1A →	-0.873	-0.779	.004	.004	3	4
BREAST	SPEN →	-0.660	-0.746	.009	.004	3	4
BLOOD_Leukemia	RHCE →	-2.391	-1.077	.005	.001	3	4
BONE	BUD13 →	-1.176	-1.409	.001	.005	3	4
BLOOD_Leukemia	KLF1 →	-3.304	-0.988	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLDA3 by Positive regulation of transforming growth factor beta production activity — BLOOD_Leukemia

Explore this box plot interactively →