Positive regulation of transforming growth factor beta production

Across TCGA cell cohorts, RNA activity of the Positive regulation of transforming growth factor beta production pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS1, ATP6AP2, and SCRN1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transforming growth factor beta production activity versus THBS1 in BLOOD_Myeloma (Pearson r = 0.93).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	THBS1 →	+3.242	+1.861	<.001	<.001	3	20
LIVER	ATP6AP2 →	+1.691	+2.080	.004	<.001	3	7
CNS	SCRN1 →	-1.602	-1.025	<.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	CHMP1B →	-1.094	-0.992	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	SSR4 →	+0.626	+1.070	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	GTF2F1 →	-1.004	-1.062	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071636 vs THBS1 — BLOOD_Myeloma

Explore this scatter interactively →