Negative regulation of transforming growth factor beta production

Across TCGA cell cohorts, RNA activity of the Negative regulation of transforming growth factor beta production pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, PLS1, and NDEL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transforming growth factor beta production activity versus FN1 in KIDNEY (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FN1 →	+5.202	+1.281	.009	.007	3	5
LIVER	PLS1 →	-1.416	-1.844	.005	<.001	3	4
LIVER	NDEL1 →	+1.043	+1.875	.008	.002	3	4
CNS	RHPN1 →	-1.618	-1.465	.001	.006	3	4
LUNG_NSCLC_LUAD	IL23A →	-1.475	-1.395	<.001	.002	3	3
LUNG_NSCLC_LUAD	CNTRL →	-1.255	-1.524	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071635 vs FN1 — KIDNEY

Explore this scatter interactively →