Regulation of granulocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of granulocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGDH, APOE, and MIR1915HG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of granulocyte chemotaxis activity versus UGDH in URINARY_TRACT (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UGDH →	+0.839	+0.336	.008	.003	3	5
STOMACH	APOE →	-5.437	-0.375	<.001	<.001	3	5
STOMACH	MIR1915HG →	-1.591	-0.354	.001	<.001	3	5
KIDNEY	CMTM6 →	+1.097	+0.298	.001	.002	3	5
URINARY_TRACT	RPH3AL →	+1.545	+0.385	.006	.002	3	4
KIDNEY	DUSP16 →	+1.215	+0.431	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071622 vs UGDH — URINARY_TRACT

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