Transforming growth factor beta production

Across TCGA cell cohorts, RNA activity of the Transforming growth factor beta production pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIPC, RNPS1, and ZNF205, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transforming growth factor beta production activity versus CIPC in SKIN (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CIPC →	-0.568	-0.792	.001	.008	1	6
LUNG_SCLC	RNPS1 →	-0.717	-2.240	<.001	<.001	3	4
URINARY_TRACT	ZNF205 →	-0.826	-0.575	.001	.001	3	3
KIDNEY	CELF1 →	-0.673	-0.821	.003	<.001	3	3
KIDNEY	DCTN5 →	-0.662	-0.643	<.001	.001	3	3
KIDNEY	DNAJC11 →	-1.056	-0.808	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071604 vs CIPC — SKIN

Explore this scatter interactively →