Protein ufmylation

Across TCGA patient cohorts, RNA activity of the Protein ufmylation pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USF3, ACAD11, and UBA5, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein ufmylation activity versus USF3 in DLBC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	USF3 →	+1.275	+0.069	<.001	<.001	3	33
KIRC	ACAD11 →	+0.736	+0.052	<.001	<.001	3	33
UVM	UBA5 →	+1.297	+0.085	<.001	<.001	3	33
DLBC	NFAT5 →	+1.738	+0.069	<.001	<.001	3	32
DLBC	MED23 →	+1.199	+0.070	<.001	<.001	3	32
UVM	SLC25A36 →	+1.747	+0.082	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071569 vs USF3 — DLBC

Explore this scatter interactively →