Protein ufmylation

Across TCGA patient cohorts, RNA activity of the Protein ufmylation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SL296P, ZNF16, and ZNF543, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein ufmylation activity versus RN7SL296P in PDAC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RN7SL296P →	+0.471	+0.122	.005	.003	3	4
LUAD	ZNF16 →	-0.320	-0.095	.003	.006	3	3
PDAC	ZNF543 →	-0.268	-0.112	.001	<.001	3	3
CCRCC	NRP2 →	-0.502	-0.076	.001	.004	3	3
CCRCC	UXT →	-0.183	-0.070	.002	.008	3	3
CCRCC	SLC6A6 →	-0.562	-0.091	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071569 vs RN7SL296P — PDAC

Explore this scatter interactively →