Protein ufmylation

Across TCGA cell cohorts, RNA activity of the Protein ufmylation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMX, RRP12, and XAF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBMX grouped by Protein ufmylation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RBMX →	-0.596	-1.080	.001	.001	3	6
PANCREAS	RRP12 →	-0.798	-0.621	<.001	.009	3	5
PANCREAS	XAF1 →	+2.789	+0.951	<.001	.004	3	5
PANCREAS	HSH2D →	+1.772	+0.671	.002	.004	3	5
STOMACH	IL1RAP →	+2.025	+1.644	.006	<.001	3	5
STOMACH	PITPNM3 →	+1.201	+1.261	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBMX by Protein ufmylation activity — PANCREAS

Explore this box plot interactively →