Protein ufmylation

Across TCGA cell cohorts, RNA activity of the Protein ufmylation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UFM1, COG6, and N4BP2L2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein ufmylation activity versus UFM1 in URINARY_TRACT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UFM1 →	+1.256	+0.137	<.001	.002	3	15
LUNG_SCLC	COG6 →	+0.933	+0.101	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	N4BP2L2 →	+0.992	+0.086	.003	.001	3	14
STOMACH	COG3 →	+0.932	+0.145	.002	<.001	3	13
BLOOD_Lymphoma	UFL1 →	+1.083	+0.132	<.001	<.001	3	11
BONE	SLC33A1 →	+0.797	+0.084	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071569 vs UFM1 — URINARY_TRACT

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