Protein ufmylation

Across TCGA cell cohorts, RNA activity of the Protein ufmylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UFL1, PEX7, and PDSS2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein ufmylation activity versus UFL1 in BLOOD_Lymphoma (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	UFL1 →	+1.021	+0.252	.009	.005	2	11
LUNG_NSCLC_LUAD	PEX7 →	+0.577	+0.190	<.001	<.001	3	7
LARGE_INTESTINE	PDSS2 →	+0.609	+0.169	<.001	<.001	3	6
BLOOD_Lymphoma	ERLEC1 →	+1.228	+0.310	.001	.001	3	6
LUNG_NSCLC_LUAD	FUCA2 →	+1.419	+0.208	.004	.002	3	6
LUNG_NSCLC_LUAD	ZUP1 →	+0.581	+0.243	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071569 vs UFL1 — BLOOD_Lymphoma

Explore this scatter interactively →