Response to transforming growth factor beta

Across TCGA cell cohorts, RNA activity of the Response to transforming growth factor beta pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSD3, SLK, and TGFB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NSD3 grouped by Response to transforming growth factor beta-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NSD3 →	-0.173	-0.216	<.001	.002	3	4
LIVER	SLK →	-0.168	-0.161	.001	.003	3	4
BREAST	TGFB1 →	-0.152	-0.095	.001	.002	2	5
STOMACH	JMJD4 →	-0.205	-0.170	.003	.007	3	4
UPPER_AERODIGESTIVE_TRACT	P2RY10 →	-0.115	-0.144	.006	.003	3	4
LUNG_NSCLC_LUSC	MSH5-SAPCD1 →	-0.200	-0.126	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NSD3 by Response to transforming growth factor beta activity — OVARY

Explore this box plot interactively →