Response to transforming growth factor beta

Across TCGA cell cohorts, RNA activity of the Response to transforming growth factor beta pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL4A5, JAG1, and UCK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to transforming growth factor beta activity versus COL4A5 in LUNG_NSCLC_LUAD (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COL4A5 →	-1.730	-0.589	.006	.001	3	4
KIDNEY	JAG1 →	-1.844	-0.141	.008	.004	3	3
BLOOD_Leukemia	UCK2 →	+0.547	+0.134	.001	<.001	3	3
STOMACH	LAMA3 →	-3.905	-0.272	.004	.006	3	3
BREAST	UPF1 →	+0.487	+0.152	.001	.001	3	3
BONE	PHLDB2 →	-2.059	-0.331	.003	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071559 vs COL4A5 — LUNG_NSCLC_LUAD

Explore this scatter interactively →