Cellular response to dexamethasone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to dexamethasone stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAB2_S723, TUBB6, and DNM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to dexamethasone stimulus activity versus DAB2_S723 in UCEC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DAB2_S723 →	+0.717	+0.067	.001	<.001	3	8
COAD	TUBB6 →	+0.389	+0.027	<.001	<.001	3	6
COAD	DNM1 →	+0.332	+0.022	.002	.003	3	6
BRCA	PRKG1 →	+0.524	+0.038	<.001	<.001	3	6
UCEC	GSTM2 →	+0.806	+0.056	<.001	.001	3	6
BRCA	COMP →	+0.755	+0.026	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071549 vs DAB2_S723 — UCEC

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