Cellular response to dexamethasone stimulus

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to dexamethasone stimulus pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Cellular response to dexamethasone stimulus pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and UCS, show the opposite pattern, with higher activity associated with better survival.

UVM, OV, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.176	0.819	<.001	84	view →
OV	DFS	Tertile	All	0.448	0.609	<.001	60	view →
KIRC	DFS	Quartile	All	0.475	0.673	<.001	53	view →
BRCA	DFS	Tertile	III,IV	0.942	0.733	<.001	42	view →
MESO	OS	Median	All	0.287	0.471	.004	35	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	29	view →
UCS	DFS	Tertile	IV	0.942	0.403	.024	24	view →
ACC	DFS	Quartile	II,III,IV	0.540	0.794	.014	17	view →
LIHC	DFS	Quartile	All	0.287	0.481	<.001	16	view →
SARC	DFS	Median	All	0.443	0.572	.013	14	view →
BLCA	DFS	Tertile	All	0.251	0.484	.042	13	view →
READ	OS	Median	II,III,IV	0.855	0.487	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0071549–UVM (DFS)

Open the UVM breakdown →