Cellular response to dexamethasone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to dexamethasone stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSS1, KLHL32, and ZNF551, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACSS1 grouped by Cellular response to dexamethasone stimulus-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ACSS1 →	+0.276	+0.131	.007	.002	3	4
PANCREAS	KLHL32 →	-0.194	-0.113	.001	.006	3	4
BLOOD_Leukemia	ZNF551 →	+0.176	+0.126	.005	<.001	3	4
OESOPHAGUS	CCDC14 →	+0.100	+0.130	.009	.001	3	4
LARGE_INTESTINE	HBEGF →	-0.221	-0.149	<.001	<.001	3	4
LARGE_INTESTINE	SYT12 →	-0.216	-0.147	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACSS1 by Cellular response to dexamethasone stimulus activity — PANCREAS

Explore this box plot interactively →