Cellular response to dexamethasone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to dexamethasone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSN, AP1S2, and OCLN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to dexamethasone stimulus activity versus MSN in URINARY_TRACT (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MSN →	-4.035	-0.246	.003	.003	3	5
OVARY	AP1S2 →	-2.297	-0.266	.006	.003	3	5
LARGE_INTESTINE	OCLN →	+1.124	+0.239	.001	<.001	3	5
LIVER	ARRDC1 →	+0.885	+0.288	.001	.003	3	5
BLOOD_Myeloma	B9D2 →	-1.204	-0.265	<.001	.003	3	4
URINARY_TRACT	FGD1 →	-1.436	-0.279	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071549 vs MSN — URINARY_TRACT

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