Dopaminergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Dopaminergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC7, CTBP1-AS, and HMGN2P8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopaminergic neuron differentiation activity versus CDC7 in BRCA (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDC7 →	-0.557	-0.105	<.001	<.001	3	4
CCRCC	CTBP1-AS →	-0.292	-0.354	.002	.001	3	3
COAD	HMGN2P8 →	+0.227	+0.286	.005	.005	3	3
COAD	SNORD11B →	-0.599	-0.467	.004	<.001	3	3
BRCA	CDC20 →	-0.894	-0.136	.007	<.001	3	3
LSCC	POF1B →	+1.463	+0.541	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071542 vs CDC7 — BRCA

Explore this scatter interactively →