Dopaminergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the Dopaminergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS8, FDXR, and HPX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HAUS8 grouped by Dopaminergic neuron differentiation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HAUS8 →	-0.784	-0.318	.006	<.001	3	4
URINARY_TRACT	FDXR →	+2.123	+0.472	.008	.002	2	4
SOFT_TISSUE	HPX →	-0.464	-0.314	.004	<.001	3	3
SOFT_TISSUE	CRTC3 →	-1.164	-0.358	<.001	<.001	3	3
SOFT_TISSUE	RPS3 →	+1.099	+0.345	.005	<.001	2	4
SOFT_TISSUE	SPNS1 →	-0.871	-0.241	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HAUS8 by Dopaminergic neuron differentiation activity — PANCREAS

Explore this box plot interactively →