Dopaminergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the Dopaminergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASSF1, SELENOS, and TLCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopaminergic neuron differentiation activity versus RASSF1 in SOFT_TISSUE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RASSF1 →	+0.846	+0.392	.008	<.001	3	5
SOFT_TISSUE	SELENOS →	+0.677	+0.426	.003	.002	3	4
KIDNEY	TLCD1 →	-0.857	-0.347	.001	.002	3	4
SKIN	BMP2K →	+0.881	+0.306	.003	<.001	3	4
URINARY_TRACT	USP4 →	+0.843	+0.358	<.001	.001	3	4
LUNG_NSCLC_LUAD	MANF →	+0.749	+0.468	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071542 vs RASSF1 — SOFT_TISSUE

Explore this scatter interactively →