Semaphorin-plexin signaling pathway

Across TCGA patient cohorts, RNA activity of the Semaphorin-plexin signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCOLCE, IGFBP7, and SERBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semaphorin-plexin signaling pathway activity versus PCOLCE in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PCOLCE →	+0.591	+0.046	<.001	<.001	3	7
CCRCC	IGFBP7 →	+0.621	+0.054	<.001	<.001	3	7
OV	SERBP1 →	-0.316	-0.062	.003	<.001	3	6
OV	CNN2 →	+0.678	+0.047	.002	.009	3	6
OV	PDGFRB →	+0.394	+0.047	<.001	<.001	3	6
CCRCC	LAMC1 →	+0.403	+0.048	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071526 vs PCOLCE — OV

Explore this scatter interactively →