Semaphorin-plexin signaling pathway

Across TCGA patient cohorts, RNA activity of the Semaphorin-plexin signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR2A, LMOD1, and ANTXR1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semaphorin-plexin signaling pathway activity versus FCGR2A in OV (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FCGR2A →	+1.039	+0.742	.001	.002	3	8
BRCA	LMOD1 →	+1.115	+1.064	<.001	<.001	3	8
OV	ANTXR1 →	+0.865	+0.681	<.001	<.001	3	8
OV	MEIS3 →	+0.855	+0.751	<.001	<.001	3	8
OV	TPM2 →	+0.883	+0.677	<.001	<.001	3	8
OV	FAP →	+1.546	+0.642	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071526 vs FCGR2A — OV

Explore this scatter interactively →