Cellular response to heparin

Across TCGA patient cohorts, RNA activity of the Cellular response to heparin pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NES, SFRP1, and ADH1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to heparin activity versus NES in BRCA (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NES →	+0.755	+0.102	<.001	<.001	3	7
BRCA	SFRP1 →	+1.239	+0.140	<.001	<.001	3	6
PDAC	ADH1B →	+0.801	+0.117	<.001	<.001	3	6
BRCA	RSU1 →	+0.487	+0.120	<.001	<.001	3	5
BRCA	SEPTIN7 →	+0.298	+0.095	<.001	.001	3	5
UCEC	SLIT2 →	+0.579	+0.129	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071504 vs NES — BRCA

Explore this scatter interactively →