Cellular response to heparin

Across TCGA patient cohorts, RNA activity of the Cellular response to heparin pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BOC, KIAA1755, and SFRP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to heparin activity versus BOC in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BOC →	+0.767	+0.760	<.001	.002	3	5
HNSC	KIAA1755 →	+0.547	+0.660	.003	<.001	3	5
CCRCC	SFRP1 →	+1.514	+0.163	<.001	.006	3	4
CCRCC	TSHZ1 →	+0.382	+0.197	.003	.007	3	4
PDAC	TACC1 →	+0.391	+0.153	<.001	<.001	3	4
LUAD	FAM13C →	+0.408	+0.639	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071504 vs BOC — LSCC

Explore this scatter interactively →