Cellular response to heparin

Across TCGA cell cohorts, RNA activity of the Cellular response to heparin pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF5, TRIM25, and CD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF5 grouped by Cellular response to heparin-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KLF5 →	+0.382	+0.157	.009	.002	3	4
STOMACH	TRIM25 →	-0.221	-0.182	.002	<.001	3	4
CNS	CD4 →	+0.147	+0.683	<.001	.002	3	4
OESOPHAGUS	HRH1 →	-0.117	-0.279	.004	.002	3	4
BONE	LINC00671 →	+0.305	+2.083	.006	.001	3	4
LUNG_SCLC	TRPM1 →	+0.151	+1.336	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF5 by Cellular response to heparin activity — STOMACH

Explore this box plot interactively →