Response to heparin

Across TCGA patient cohorts, RNA activity of the Response to heparin pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLIT2, RSU1, and SFRP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to heparin activity versus SLIT2 in UCEC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLIT2 →	+0.697	+0.113	<.001	.005	2	8
BRCA	RSU1 →	+0.450	+0.110	<.001	<.001	3	6
BRCA	SFRP1 →	+1.061	+0.099	<.001	<.001	3	6
BRCA	SOD3 →	+0.741	+0.070	.001	.001	3	6
UCEC	TGFB1I1_S192 →	+0.736	+0.115	.006	.005	3	5
BRCA	ROCK2 →	+0.226	+0.075	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071503 vs SLIT2 — UCEC

Explore this scatter interactively →