Response to heparin

Across TCGA patient cohorts, RNA activity of the Response to heparin pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP22, TACC1, and KRT8P13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to heparin activity versus DUSP22 in LUAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DUSP22 →	+0.244	+0.525	.004	.004	3	4
PDAC	TACC1 →	+0.299	+0.192	.001	.001	3	4
PDAC	KRT8P13 →	+0.253	+0.172	.008	.001	3	4
BRCA	SFRP1 →	+2.221	+0.570	<.001	.009	1	5
BRCA	ZNF767P →	+0.425	+0.411	<.001	.005	3	3
BRCA	DZIP1 →	+0.668	+0.655	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071503 vs DUSP22 — LUAD

Explore this scatter interactively →