Response to heparin

Across TCGA cell cohorts, RNA activity of the Response to heparin pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTPBP10, SRY, and IL21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTPBP10 grouped by Response to heparin-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GTPBP10 →	-0.161	-1.088	.003	.003	3	4
BLOOD_Myeloma	SRY →	+0.205	+1.520	.002	<.001	3	4
OESOPHAGUS	IL21 →	-0.177	-0.277	.001	<.001	3	3
OESOPHAGUS	FARS2 →	+0.197	+0.212	.004	.005	3	3
OESOPHAGUS	FAM161A →	-0.237	-0.298	.001	.006	3	3
STOMACH	CSNK1A1 →	+0.334	+0.253	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTPBP10 by Response to heparin activity — KIDNEY

Explore this box plot interactively →