Cellular response to laminar fluid shear stress

Across TCGA patient cohorts, RNA activity of the Cellular response to laminar fluid shear stress pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAVIN2, KANK2, and RSU1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to laminar fluid shear stress activity versus CAVIN2 in CCRCC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CAVIN2 →	+0.662	+0.048	<.001	.002	3	9
UCEC	KANK2 →	+0.586	+0.097	<.001	<.001	3	9
UCEC	RSU1 →	+0.428	+0.095	<.001	<.001	3	8
UCEC	SYNPO2 →	+0.723	+0.111	<.001	<.001	3	8
HNSC	SYNPO2_S930 →	+0.962	+0.054	<.001	.004	3	8
UCEC	TLN1 →	+0.335	+0.093	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071499 vs CAVIN2 — CCRCC

Explore this scatter interactively →