Cellular response to UV-A

Across TCGA patient cohorts, RNA activity of the Cellular response to UV-A pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDB1, MME, and MMP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to UV-A activity versus DDB1 in BRCA (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDB1 →	-0.164	-0.080	<.001	<.001	3	7
LSCC	MME →	+1.039	+0.111	<.001	<.001	3	7
LSCC	MMP2 →	+0.634	+0.101	<.001	<.001	3	7
LUAD	SULF1 →	+0.820	+0.105	<.001	<.001	3	6
BRCA	C1S →	+0.418	+0.084	<.001	<.001	3	6
COAD	ANTXR1 →	+0.600	+0.104	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071492 vs DDB1 — BRCA

Explore this scatter interactively →